Other fibrotic phenomena reduce life quality in scleroderma, hypertrophic scars (remarkably severe after large burn wounds), chronic asthma and Dupuytren's disease. Moreover, myofibroblasts at the tumor invasion front are activated by the transformed epithelium to stimulate tumor growth and invasion by promoting angiogenesis and tumor cell migration. In tissue engineering and regenerative medicine considerable effort is required to prevent myofibroblast formation, either arising from mesenchymal stem cells that are implanted to repair tissues or at the interface between the implant and the host connective tissue. But don't be fooled - the myofibroblast is not necessarily the 'bad guy' as it contributes to physiological wound healing and its absence has been associated with development of chronic wounds. In all these conditons, controlling the tissue activity of myofibroblasts will be beneficial for the outcome of the body repair process.