2018 07 LTRROur Mission

 

We aim to understand the mechanisms controling myofibroblast function and how they influence the development of fibrosis. We carry out functional analysis of the cell's contractile apparatus (actin stress fibers), of force transmission at sites of cell-extracellular matrix contacts (focal adhesions) and of the mechanical cross-talk between contractile stress fibers of contacting fibroblasts at sites of cell-cell adherens junctions. We develop novel strategies to counteract myofibroblast malfunction by targeting these instrumental structures of the contractile phenotype.